Related Experiment Video
Updated: Aug 9, 2026
Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles
M Flock1, A Karlström, J Lannergård
1Department of Laboratory Medicine, Karolinska Institutet, Huddinge University Hospital, SE-141 86 Stockholm, Sweden.
Abstract:
A mouse model resembling Streptococcus equi subspecies equi infection in the horse, strangles, was used to assess the protective effect of vaccination with selected recombinant proteins from S. equi subsp. equi. After challenge the infection was monitored by weight loss and by nasal colonisation with S. equi subsp. equi. Vaccination with a collagen-binding protein (CNE) and a collagen-like protein (SclC) resulted in protective antibodies, whereas a novel fibronectin-binding protein (FNEB) did not. Co-administration of CNE with EAG, a poorly immunogenic alpha2-macroglobulin-, albumin- and immunoglobulin G-binding protein, resulted in a significant synergistic effect and enhanced the protective immune response against EAG.
