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Updated: Aug 9, 2026

Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
Rediscovery of natural products using genomic tools
Akira Kawamura1, Angelika Brekman, Yevgeniy Grigoryev
1CUNY-Hunter College, Department of Chemistry, 695 Park Avenue, New York, NY 10021, USA. akira.kawamura@hunter.cuny.edu
Abstract:
A screening methodology called 'genomic screening' was established to identify natural products that can regulate cellular gene expression. Application of genomic screening to Keishi-bukuryo-gan (KBG), a Japanese herbal medicine formulation, identified a previously unnoticed transcriptional effect by linoleic acid, a known KBG component. The approach opens up a possibility to develop cell-permeable molecular tools for functional genomics research and sets a stage to evaluate the potential of natural products for transcription therapies.
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