Related Experiment Videos
Gestrinone versus danazol as preoperative treatment for hysteroscopic surgery: a prospective, randomized evaluation
Onofrio Triolo1, Antonio De Vivo, Vincenzo Benedetto
1Department of Gynecological, Obstetrical Sciences and Reproductive Medicine, University of Messina, Messina, Italy. otriolo@unime.it
Objective:
To compare danazol and gestrinone treatment as preoperative endometrial preparation for operative hysteroscopy.
Design:
Prospective, randomized clinical study.
Setting:
University department of gynecological, obstetrical sciences and reproductive medicine.
Patient(S):
One hundred thirty-five patients with endouterine pathologies (endometrial polyps, submucous myoma, septate uterus).
Intervention(S):
Patients pretreated with gestrinone (n = 68) and with danazol (n = 67) underwent operative hysteroscopy.
Main Outcome Measure(S):
Endometrial response to the medical pretreatment, side effects, procedure time, intraoperative bleeding, infusion volume, patient satisfaction.
Result(S):
Side effects were infrequent in both groups, though the patients' personal satisfaction was in favor of gestrinone. The rate of endometrial response was higher for the gestrinone group (97.1% vs. 83.6%). Operative time (mean +/- SD) was 12 +/- 1.8 and 15.2 +/- 1.9 minutes for the gestrinone and danazol groups, respectively. The gestrinone group showed a lower incidence of moderate bleeding (3% vs. 22.4%) and a lower infusion volume (2,100 +/- 200 mL vs. 2,400 +/- 250 mL). Regarding cervical dilatation time, no significant difference was found between the two groups (1.6 +/- 0.3 minutes vs. 1.5 +/- 0.4 minutes).
Conclusion(S):
Both treatments are good ways to prepare the endometrium for operative hysteroscopy. However, the data suggest that gestrinone pretreatment is preferable to danazol.