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Characterization of a de novo balanced 1;Y translocation in a phenotypically normal twin male infant

Hariklia Hatzissevastou-Loukidou1, Theodora G Kalemi, Alexandros F Lambropoulos

  • 1First Department of Pediatrics, Hippocration General Hospital, Thessaloniki, Greece.

Fertility and Sterility
|April 4, 2006
PubMed
Abstract

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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...
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The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
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