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Defining and maintaining a high quality screening collection: the GSK experience
Stephen J Lane1, Drake S Eggleston, Keith A Brinded
1CASS, DR, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, UK. stephen.j.lane@gsk.com
Drug Discovery Today
|April 4, 2006
Summary
Improving screening collection quality is crucial for better drug discovery processes. This involves assessing current collections and implementing necessary infrastructure for enhanced data mining and modeling.
Area of Science:
- Drug discovery and development
- Chemical and biological screening
Background:
- Assessing screening collection quality is essential for optimizing drug discovery.
- Previous efforts lacked a systematic approach to quality assessment.
Purpose of the Study:
- To outline a methodology for assessing and improving screening collection quality.
- To detail the infrastructure requirements for successful implementation.
Main Methods:
- Focus on software and hardware infrastructure.
- Implementation of quality assessment protocols.
- Exploration of data mining and modeling benefits.
Main Results:
- Identification of key infrastructure needs.
- Overcoming specific project hurdles.
- Demonstration of enhanced data analysis capabilities.
Conclusions:
- A systematic approach to screening collection quality is vital.
- Adequate infrastructure underpins successful screening processes.
- Data mining and modeling offer significant added value.
