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Updated: Aug 9, 2026

Surgical Angiogenesis in Porcine Tibial Allotransplantation: A New Large Animal Bone Vascularized Composite Allotransplantation Model
Published on: August 13, 2017
Vascularised bone grafts for the management of non-union
Panayotis N Soucacos1, Zoe Dailiana, Alexandros E Beris
1Department of Orthopaedic Surgery, University of Athens, School of Medicine, K.A.T. Accident Hospital, 2 Nikis Street, 145 61 Kifisia, Athens, Greece. soukakos@panafonet.gr
Abstract:
Non-union of the long bones may have severe consequences, particularly when combined with other post-traumatic sequelae, such as tendon adhesions, reflex sympathetic dystrophy and infection, among others. In these cases, it is important to treat the delayed union or non-union first or at the same time with the other problems in order to achieve adequate function. Once the normal bony healing process has been slowed or stopped, it is necessary to provide both stability to the fracture site, as well as a biological stimulus for the fibrocartilagenous callus to finish the healing process. Vascularised grafts, such as the free fibula, offer not only structural support, but also promote bone healing. The later is achieved by trabecular bone formation, as well as vascular sprouting from pedicle vessels.
