Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is asthma research in dead end?

Annette Amon1, Andreas Pahl, Istvan Szelenyi

  • 1Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen, Fahrstr. 17, 91054 Erlangen, Germany.

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie
|April 4, 2006
PubMed
Summary

New asthma treatments are urgently needed as single-target drugs are ineffective. Future research should focus on novel, multi-action therapies and serendipity-based drug discovery for better asthma management.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

pH-Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma.

Acta physiologica (Oxford, England)·2026
Same author

ETx-22, a Novel Nectin-4-Directed Antibody-Drug Conjugate, Demonstrates Safety and Potent Antitumor Activity in Low-Nectin-4-Expressing Tumors.

Cancer research communications·2024
Same author

Site-Specific Modification of Native IgGs with Flexible Drug-Load.

Chembiochem : a European journal of chemical biology·2024
Same author

Novel Anti-B-cell Maturation Antigen Alpha-Amanitin Antibody-drug Conjugate HDP-101 Shows Superior Activity to Belantamab Mafodotin and Enhanced Efficacy in Deletion 17p Myeloma Models.

Research square·2024
Same author

Anti-CD37 α-amanitin-conjugated antibodies as potential therapeutic weapons for Richter syndrome.

Blood·2022
Same author

Iodine-Mediated Tryptathionine Formation Facilitates the Synthesis of Amanitins.

Journal of the American Chemical Society·2021

Area of Science:

  • Pulmonology
  • Pharmacology
  • Drug Discovery

Background:

  • Bronchial asthma remains a significant global health issue despite therapeutic advancements.
  • Current understanding of asthma pathogenesis has grown, yet effective treatments are still lacking.
  • Existing therapies often target single mediators, proving insufficient for comprehensive asthma control.

Purpose of the Study:

  • To highlight the limitations of current asthma treatment strategies.
  • To advocate for the development of novel therapeutic approaches for bronchial asthma.
  • To propose a shift in drug screening methodologies towards more innovative research.

Main Methods:

  • Review of current therapeutic strategies for bronchial asthma.
  • Analysis of the efficacy of single-mediator targeted drugs.

Related Experiment Videos

  • Discussion on the potential of multi-action drugs and serendipity-based research.

    • Main Results:

    • The single mediator approach has shown limited success in asthma treatment.
    • Drugs with multiple sites of action present a more promising therapeutic avenue.
    • Current drug screening strategies may require re-evaluation.

    Conclusions:

    • There is a critical need for new and more effective treatments for bronchial asthma.
    • Multi-target drugs offer greater potential for successful therapeutic introduction.
    • A move towards serendipity-based research could accelerate the discovery of novel asthma therapies.