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Updated: Jan 9, 2026

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Thermodynamics Of alpha-Helix Formation
1Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033.
Abstract:
The alpha-helix was the first proposed and experimentally confirmed secondary structure. The elegant simplicity of the alpha-helical structure, stabilized by hydrogen bonding between the backbone carbonyl oxygen and the peptide amide four residues away, has captivated the scientific community. In proteins, alpha-helices are also stabilized by the so-called capping interactions that occur at both the C- and the N-termini of the helix. This chapter provides a brief historical overview of the thermodynamic studies of the energetics of helix formation, and reviews recent progress in our understanding of the thermodynamics of helix formation.
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