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Published on: February 26, 2013
Cardioversion in patients with left ventricular thrombus is not associated with increased thromboembolic risk
Sripal Bangalore1, Luiza Petre, Bengt Herweg
1Division of Cardiology, Department of Medicine, St Luke's-Roosevelt Hospital Center and Columbia University College of Physicians and Surgeons, New York, New York 10025, USA.
Insights
Systemic embolism was not observed after cardioversion in patients with left ventricular (LV) thrombus. This study suggests cardioversion may be safe in this population, warranting further investigation.
Area of Science:
- Cardiology
- Cardiac Electrophysiology
- Echocardiography
Background:
- Systemic embolization risk after cardioversion is known for atrial thrombus but limited for left ventricular (LV) thrombus.
- Hesitancy to perform cardioversion in patients with LV thrombus exists due to potential thromboembolic risks.
- Limited data necessitates further research into cardioversion safety in LV thrombus patients.
Purpose of the Study:
- To determine the incidence of systemic embolism following cardioversion in patients diagnosed with left ventricular (LV) thrombus.
- To evaluate the safety and efficacy of cardioversion in a population with known LV thrombus.
- To provide data on thromboembolic events in patients undergoing cardioversion for arrhythmias with coexisting LV thrombus.
Main Methods:
- Retrospective review of transthoracic and transesophageal echocardiograms (1996-2001) to identify patients with LV thrombus.
- Analysis of medical records for patients who underwent cardioversion within three weeks of echocardiographic diagnosis.
- Assessment of clinical outcomes, including embolic events, during hospitalization and up to one year of follow-up.
Main Results:
- Twenty-one patients with LV thrombus (mean age 66 years, ejection fraction 22%) underwent cardioversion.
- Cardioversion was performed for atrial fibrillation (38%) and ventricular tachyarrhythmia (62%), with varying urgency.
- No patient experienced a clinically apparent embolic event, including stroke, during the follow-up period.
Conclusions:
- Cardioversion in patients with echocardiographically confirmed left ventricular (LV) thrombus was not associated with systemic embolism.
- The findings suggest that cardioversion may be a safe procedure in this patient group.
- Further prospective studies are recommended to confirm the safety and efficacy of cardioversion in patients with LV thrombus.
Objectives:
The purpose of the study was to define the incidence of systemic embolism after cardioversion in patients with left ventricular (LV) thrombus.
Background:
The risk of systemic embolization after cardioversion in patients with an atrial thrombus is well known. However, data on thromboembolic events after cardioversion in patients with LV thrombus are limited because of hesitance to perform cardioversion in this population.
Methods:
Transthoracic and transesophageal echocardiograms acquired between January 1996 and October 2001 at our institution were reviewed for presence of LV thrombus in two orthogonal apical views. A total of 413 patients had echocardiographic evidence of LV thrombus. Medical records were reviewed for cardioversion performed within 3 weeks of the echocardiogram.
Results:
A total of 21 patients, age 66 +/- 10 years and ejection fraction 22 +/- 10% were identified. Cardioversion was indicated for atrial fibrillation in 8 (38%) and ventricular tachyarrhythmia in 13 (62%) patients, and was performed emergently in 5 (24%), electively in 8 (38%), and during electrophysiology study in 8 (38%) patients. The time interval between diagnostic echocardiographic study and cardioversion was 6 +/- 5 (range 1-18) days. All thrombi were located in the apical LV and were described as laminated (71%) and protruding (29%), and measured 0.7 +/- 0.4 x 1.6 +/- 0.8 cm. Before cardioversion, 17 (81%) patients were anticoagulated with warfarin or heparin. During clinical follow-up of up to 1 year (153 +/- 150 days) anticoagulation with warfarin was given to 15 (71%) patients. No patient had clinically apparent embolic event, including stroke, during hospitalization or during outpatient follow-up.
Conclusions:
Embolism after cardioversion in patients with echocardiographic evidence of LV thrombus was not observed. Cardioversion seems to be safe and further prospective studies are needed to address this.
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