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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
Published on: May 8, 2013
Risk factors for specific methicillin-resistant Staphylococcus aureus clones in a Korean hospital
Dong Taek Cho1, Hwa Yun Cha, Hyun-Ha Chang
1Department of Microbiology, Kyungpook National University School of Medicine, Daegu 700-422, Korea.
Objectives:
To analyse the risk factors for nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infections caused by different clonal types.
Methods:
A total of 134 non-duplicate nosocomial MRSA isolates were analysed for clonal types by molecular typing techniques. The medical records of 90 patients who had documented MRSA infection were evaluated retrospectively.
Results:
Two predominant MRSA clones of sequence types (STs) ST239 (n = 75) and ST5 (n = 39) accounted for 85% of the isolates. Management of patients in the departments of orthopaedic surgery, neurosurgery and plastic surgery was identified as a risk factor for infection with MRSA of ST239, while the presence of intravascular catheters was a risk factor for infection with ST5. Pulmonary infection was significantly higher in the patients infected with ST239 strains than in the patients infected with ST5 strains (P < 0.05). The overall mean duration of antimicrobial therapy for the patients with ST239 infection was significantly more than that for the patients with ST5 infection (P < 0.05).
Conclusions:
ST239 and ST5 were the predominant MRSA clones in the study hospital. Risk factors were significantly different between ST239 and ST5 strains. The results of this study will be of use in designing larger prospective epidemiological studies for MRSA infection based on clonal types.
Insights
Two main types of methicillin-resistant Staphylococcus aureus (MRSA) cause hospital infections. Different patient care factors are linked to each MRSA clonal type, ST239 and ST5, impacting treatment and outcomes.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Epidemiology
Background:
- Nosocomial infections pose a significant threat in healthcare settings.
- Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infections.
- Understanding the epidemiology of different MRSA strains is crucial for effective control.
Purpose of the Study:
- To investigate the risk factors associated with nosocomial infections caused by distinct clonal types of MRSA.
- To differentiate the epidemiological characteristics of predominant MRSA clones.
Main Methods:
- Molecular typing techniques were employed to determine the clonal types of 134 nosocomial MRSA isolates.
- Retrospective analysis of medical records for 90 patients with documented MRSA infections.
Main Results:
- Two predominant MRSA clones, ST239 (75 isolates) and ST5 (39 isolates), constituted 85% of all isolates.
- Risk factors for ST239 infection included management in orthopaedic, neurosurgery, and plastic surgery departments.
- Intravascular catheter use was a risk factor for ST5 infection, which was also associated with higher rates of pulmonary infection and longer antimicrobial therapy durations.
Conclusions:
- ST239 and ST5 are the dominant MRSA clones in the studied hospital.
- Significant differences in risk factors exist between ST239 and ST5 MRSA infections.
- Findings support the design of prospective epidemiological studies focusing on MRSA clonal types.
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