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Related Experiment Videos

Korean red ginseng rootlets decrease acute postprandial glycemia: results from sequential preparation- and

John L Sievenpiper1, Mi-Kyung Sung, Marco Di Buono

  • 1Department of nutritional sciences, Faculty of Medicine, University of Toronto, Canada.

Journal of the American College of Nutrition
|April 4, 2006
PubMed
Summary

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Korean red ginseng (KRG) rootlets effectively reduce postprandial blood glucose levels. A 2g dose of KRG rootlets is sufficient for reproducible glycemic control, though long-term effects require further study.

Area of Science:

  • Nutritional Science
  • Pharmacology
  • Metabolic Health

Background:

  • Ginsenoside profiles in Korean red ginseng (KRG) may impact postprandial glycemia.
  • Investigating different KRG root fractions is crucial for identifying efficacious preparations for blood sugar management.
  • This study aimed to find an effective KRG preparation for future long-term research.

Purpose of the Study:

  • To determine if KRG fractionation influences its effect on postprandial glycemia.
  • To identify the most efficacious KRG fraction for glycemic control.
  • To establish an effective dose of the identified KRG fraction.

Main Methods:

  • A double-blind, randomized, within-subject design was employed for both preparation-finding and dose-finding studies.

Related Experiment Videos

  • Participants underwent oral glucose tolerance tests (OGTT) after consuming placebo or different KRG fractions (rootlets, body, H2O extract).
  • Ginsenoside analysis was performed using High-Performance Liquid Chromatography with Ultraviolet detection (HPLC-UV).

    • Main Results:

    • KRG rootlets significantly reduced the area under the curve (AUC) of postprandial blood glucose by 29% compared to placebo (p=0.052).
    • Ginsenoside Rg1 was identified as the sole predictor of mean and AUC postprandial blood glucose.
    • A mean dose of 2g KRG rootlets decreased AUC by 17% versus placebo (p=0.057), indicating a significant treatment effect.

    Conclusions:

    • Two grams of KRG rootlets are sufficient to achieve reproducible reductions in postprandial glycemia.
    • The study identified KRG rootlets as a promising intervention for managing blood sugar levels.
    • Long-term efficacy and sustainability of KRG selected through this method warrant further investigation.