Cyclin e overexpression reduces infiltrative growth in breast cancer: yet another link between proliferation control
Pontus Berglund1, Göran Landberg
1Pathology, Department of Laboratory Medicine, Lund University, Malmö University Hospital, Malmö, Sweden.
Cell Cycle (Georgetown, Tex.)
|April 4, 2006
Abstract:
Overexpression of cyclin E is strongly linked to an aggressive phenotype and poor prognosis in breast cancer. Unexpectedly, it has been shown that cyclin E overexpression decreases mobility and invasiveness of breast cancer cells. In fact, in a study of 985 breast cancers, cyclin E correlated with less infiltrative growth. This suggests a novel function for cyclin E in breast cancer tumorigenesis and a mutual control of proliferation and invasive behavior.
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