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Shedding light on mammary stem cells and tumorigenesis

Geoffrey J Lindeman1, Jane E Visvader

  • 1The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 350, Australia. lindeman@wehi.edu.au

Cell Cycle (Georgetown, Tex.)
|April 4, 2006
PubMed
Abstract

No abstract available in PubMed .

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...