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An update on osteoarthritis therapeutics
M Scott Hogenmiller1, Carlos J Lozada
1Department of Medicine, Jackson Memorial Hospital, Miami, Florida, USA.
Current Opinion in Rheumatology
|April 4, 2006
Summary
Osteoarthritis (OA) treatment focuses on symptom relief and disease modification. Recent findings on cyclo-oxygenase-2 inhibitors and glucosamine, alongside intra-articular injections, require clinicians to reassess OA therapy strategies.
Area of Science:
- Rheumatology
- Pharmacology
- Biochemistry
Background:
- Osteoarthritis (OA) management requires balancing symptomatic relief with disease modification.
- Clinicians need updated information on therapeutic options for OA.
- Research is advancing to identify agents that can slow OA progression.
Purpose of the Study:
- To review recent developments in symptomatic therapy for osteoarthritis.
- To discuss principles of disease modification in osteoarthritis.
- To highlight key issues for clinicians managing osteoarthritis.
Main Methods:
- Review of recent clinical trials and published reports.
- Assessment of cyclo-oxygenase-2 inhibitors and nutraceuticals (e.g., glucosamine).
- Evaluation of intra-articular injections (corticosteroids, hyaluronic acid).
Main Results:
- Reassessment of cyclo-oxygenase-2 inhibitors' role in OA therapy.
- New data on glucosamine efficacy and intra-articular injection effectiveness.
- Publication of trials investigating potentially disease-modifying agents for OA.
Conclusions:
- Reduced therapeutic options and unclear role of supplements necessitate reassessment of OA treatment.
- No practical disease-modifying agent for OA identified yet.
- Ongoing research, like the doxycycline trial, offers hope for future disease-modifying therapies similar to rheumatoid arthritis treatment.
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