Related Experiment Video

Updated: Aug 9, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Stature in children with chronic kidney disease: analysis of NAPRTCS database

Mouin G Seikaly1, Nina Salhab, Debbie Gipson

  • 1Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Mouin.Seikaly@UTSouthwestern.edu

Pediatric Nephrology (Berlin, Germany)
|April 4, 2006
PubMed

Insights

Short stature in children with chronic kidney disease (CKD) is linked to several factors. Older age, higher kidney function, Black race, and specific diagnoses like focal segmental glomerulosclerosis (FSGS) were associated with better height outcomes, while anemia was a risk factor.

Area of Science:

  • Pediatric Nephrology
  • Growth and Development
  • Chronic Kidney Disease (CKD)

Background:

  • Suboptimal growth remains a significant challenge in pediatric chronic kidney disease (CKD) management.
  • Understanding factors contributing to short stature is crucial for improving long-term outcomes in affected children.

Purpose of the Study:

  • To identify factors associated with short stature in children diagnosed with chronic kidney disease (CKD).
  • To analyze the relationship between clinical and demographic variables and height at entry into a large pediatric renal registry.

Main Methods:

  • Utilized data from the North American Pediatric Renal Transplant Cooperative Studies (NAPRTCS) chronic renal failure registry (1994-2004).
  • Evaluated 5,615 pediatric patients with CKD, assessing primary diagnosis, age, race, residual renal function (GFR), anemia, acidosis, and biochemical markers (phosphorous, calcium, PTH, albumin).

Main Results:

  • Older age, higher glomerular filtration rate (GFR) >50 ml/min/1.73 m², Black race, and focal segmental glomerulosclerosis (FSGS) were associated with a lower risk of short stature.
  • Anemia (hematocrit <33%) was identified as an independent risk factor for short stature.
  • Acidosis, serum phosphorous, calcium, albumin, and parathyroid hormone (PTH) were poor predictors of short stature.

Conclusions:

  • Age, race, primary kidney diagnosis, and residual renal function are significant factors associated with short stature in children with CKD.
  • Anemia is a key modifiable risk factor contributing to growth impairment in this population.
  • Further research and targeted interventions are needed to optimize growth in children with CKD.

More Related Videos

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method08:15

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

Related Concept Videos

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance (Clcr), a...
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...