Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elevation in plasma Abeta42 in geriatric depression: a pilot study.

Nunzio Pomara1, P Murali Doraiswamy, Lisa M Willoughby

  • 1Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA. pomara@nki.rfmh.org

Neurochemical Research
|April 4, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of prior pharmacotherapy on remission with sequential bilateral theta-burst versus standard bilateral repetitive transcranial magnetic stimulation in treatment-resistant late-life depression.

The British journal of psychiatry : the journal of mental science·2023
Same author

Brain-Cognition Associations in Older Patients With Remitted Major Depressive Disorder or Mild Cognitive Impairment: A Multivariate Analysis of Gray and White Matter Integrity.

Biological psychiatry·2023
Same author

Effects of antipsychotic medication on functional connectivity in major depressive disorder with psychotic features.

Molecular psychiatry·2023
Same author

Lipopolysaccharide, Immune Biomarkers and Cerebral Amyloid-Beta Deposition in Older Adults With Mild Cognitive Impairment & Major Depressive Disorder.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2023
Same author

Predictors of adherence to electronic self-monitoring in patients with bipolar disorder: a contactless study using Growth Mixture Models.

International journal of bipolar disorders·2023
Same author

Manipulating facial musculature with functional electrical stimulation as an intervention for major depressive disorder: a focused search of literature for a proposal.

Journal of neuroengineering and rehabilitation·2023

Plasma amyloid beta 1-42 (Abeta42) is elevated in late-life depression (LLMD), suggesting a potential link to Alzheimer's disease risk. These Abeta42 levels were not affected by depression onset age or antidepressant treatment.

Area of Science:

  • Neuroscience
  • Gerontology
  • Biochemistry

Background:

  • Elevated plasma amyloid beta 1-42 (Abeta42) is a known risk factor for Alzheimer's disease (AD) in cognitively intact elderly.
  • Late-life depression (LLMD), particularly with a late age of onset, is associated with an increased risk of AD.
  • Plasma Abeta levels in LLMD patients have not been previously investigated.

Purpose of the Study:

  • To compare plasma Abeta levels between elderly individuals with LLMD and healthy controls.
  • To examine the relationship between plasma Abeta levels and factors such as age of depression onset, antidepressant treatment, platelet activation, and brain abnormalities in LLMD.
  • To investigate the potential role of plasma Abeta as a biomarker in LLMD.

Main Methods:

  • Plasma Abeta42 and Abeta40 levels were measured in 47 elderly individuals with LLMD and 35 controls.

Related Experiment Videos

  • Magnetic Resonance Imaging (MRI) was used to assess brain abnormalities, specifically white matter hyperintensity burden.
  • Relationships between plasma Abeta levels, age of depression onset, antidepressant use (paroxetine or nortriptyline), platelet activation markers, and MRI findings were analyzed.

    • Main Results:

    • Plasma Abeta42 levels and the Abeta42/40 ratio were significantly elevated in the LLMD group compared to controls.
    • A higher Abeta42/40 ratio in LLMD patients correlated with a greater severity of white matter hyperintensity burden on MRI.
    • Plasma Abeta levels in LLMD were not influenced by the age of depression onset or antidepressant treatment and showed no relation to platelet activation markers.

    Conclusions:

    • Preliminary findings indicate elevated plasma Abeta42 and Abeta42/40 ratio in geriatric depression (LLMD).
    • These findings suggest a potential link between altered Abeta metabolism and LLMD.
    • Further research is warranted to confirm these results and explore their association with cognitive decline and brain abnormalities in LLMD.