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Valvular heart disease in pergolide-treated Parkinson's disease
James Scozzafava1, Jennifer Takahashi, Wendy Johnston
1Division of Neurology, University of Alberta, Edmonton, Alberta, Canada.
Background:
A 61-year-old woman with Parkinson's disease, receiving pergolide 1.75 mg four times daily, was admitted with progressive dyspnea.
Methods:
Investigations revealed mitral and aortic regurgitation. She underwent surgical mitral replacement and aortic repair, but had a post-operative course characterized by repeated bouts of congestive heart failure.
Results:
Severe tricuspid valve (TV) regurgitation developed within one month after the TV was reported on echocardiography to be relatively normal. Subsequent discontinuation of pergolide was associated with symptomatic improvement.
Conclusions:
This case illustrates the severity and rapidity with which cardiac valvular abnormalities can develop in patients receiving pergolide.
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