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Blood compatible carbon nanotubes--nano-based neoproteoglycans
Saravanababu Murugesan1, Tae-Joon Park, Hoichang Yang
1Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA.
Abstract:
Although nanotechnology has provided a rich variety of nanomaterials (1-100 nm) for in vivo medical applications, the blood compatibility of all these nanobiomaterials is still largely unexamined. Here, we report the preparation of blood-compatible carbon nanotubes (CNTs) that potentially represent the building blocks for nanodevices having in vivo applications. Activated partial thromboplastin time (APTT) and thromboelastography (TEG) studies prove that heparinization can significantly enhance the blood compatibility of nanomaterials.
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