Intermittent loading improves results in mandibular alveolar distraction osteogenesis
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Updated: Aug 9, 2026
A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
Ugo Consolo1, Carlo Bertoldi, Davide Zaffe
1Department of Neurosciences, Head-Neck, Rehabilitation, Section of Dentistry and Maxillofacial Surgery, University of Modena and Reggio Emilia, Modena, Italy.
Aim:
To evaluate clinical and morphological effects on distractive callus after application of an original protocol of bone stimulation.
Material And Methods:
Traditional or mechanically stimulated alveolar-distraction osteogenesis was studied on 16 highly selected subjects subdivided into two groups. Clinical, radiological, densitometric and histological (on biopsies) analyses were performed 6, 8 and 12 weeks after distraction was completed.
Results:
In subjects undergoing stimulated alveolar-distraction osteogenesis, bone density was higher and at histology, bone with ordered structure was observed after 6 weeks. Moreover, bone trabeculae with oriented architecture and greater amounts of lamellar bone were observed after 8 and 12 weeks in the same subjects.
Discussion And Conclusions:
In conclusion, although osteogenic processes were similar in both groups, they were induced earlier and were better structured in subjects undergoing stimulated alveolar-distraction osteogenesis. These encouraging results can only be achieved and preserved by strict monitoring of distractive vectors.
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