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Genetic control of hippocampal neurogenesis

Christine D Pozniak1, Samuel J Pleasure

  • 1Department of Neurology, Programs in Neuroscience and Developmental Biology, University of California, San Francisco, CA 94143, USA.

Genome Biology
|April 6, 2006
PubMed

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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...