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DNA strand breaks induced by near-zero-electronvolt electron attachment to pyrimidine nucleotides

Xiaoguang Bao1, Jing Wang, Jiande Gu

  • 1Drug Design and Discovery Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.

Proceedings of the National Academy of Sciences of the United States of America
|April 6, 2006
PubMed
Summary

Low-energy electrons (LEE) can induce DNA strand breaks by attaching to pyrimidine bases, forming radical anions. This process primarily involves C-O bond breaking, leading to DNA damage.

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