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Updated: Aug 9, 2026

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
Implications of quality adjusted survival for clinical trials in radiation oncology
1Birmingham Cancer Centre, University Hospital Birmingham, Birmingham B15 2TH, UK.
Abstract:
Clinical trials in radiotherapy sometimes compare changes in radiation dose distribution using different radiation techniques. The use of quality adjusted survival can, in special circumstances, reduce the requirement of large patient numbers in order to show a significant difference in overall outcome. The provisos are that marginal improvements in survival or tumour control endpoints and a reduction in toxicity scores are present. The converse findings would also be amenable to this approach. Random sampling methods are used to construct a patient population where the first set of conditions is met. Further work is necessary to refine the absolute indications for this technique.
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