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Updated: Aug 9, 2026

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain
Published on: July 11, 2016
Sigma L is important for cold shock adaptation of Bacillus subtilis
Frank Wiegeshoff1, Carsten L Beckering, Michel Debarbouille
1Philipps-Universität Marburg, FB Chemie-Biochemie, Hans-Meerwein-Strasse, D-35032 Marburg, Germany.
Abstract:
Although sigma factor-dependent transcriptional regulation was shown to be essential for adaptation to different environmental stimuli, no such sigma factor has been related to the regulation of the cold shock response in Bacillus subtilis. In this study, we present genetic evidence for participation of sigma(L) (sigma(54)) and the two sigma(L)-dependent transcriptional enhancers BkdR and YplP in the cold shock response of Bacillus subtilis JH642. Single-gene deletion of either sigL, bkdR, or yplP resulted in a cold-sensitive phenotype.
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