Related Experiment Video
Updated: Aug 9, 2026

ABCG5/G8 Crystallization in a Lipidic Bicelle Environment for X-Ray Crystallography
Published on: August 25, 2023
The ABCA subfamily--gene and protein structures, functions and associated hereditary diseases
Christiane Albrecht1, Enrique Viturro
1Physiology Weihenstephan, Technical University Munich, Freising, Germany. Christiane.Albrecht@wzw.tum.de
Abstract:
To date, 12 members of the human ABCA subfamily are identified. They share a high degree of sequence conservation and have been mostly related with lipid trafficking in a wide range of body locations. Mutations in some of these genes have been described to cause severe hereditary diseases related with lipid transport, such as fatal surfactant deficiency or harlequin ichthyosis. In addition, most of them are hypothesized to participate in the subcellular sequestration of drugs, thereby being responsible for the resistance of several carcinoma cell lines against drug treatment. The objective of this review is to summarize the literature for this subfamily of ABC transporter proteins, excluding ABCA1 and ABCA4, which will be discussed in other chapters of this issue.
Related Concept Videos
ABC Transporters: Exporter
Protein Families
Protein and Protein Structure
A protein's shape is critical to its function. For example, an enzyme can...
ABC Transporters: Importer
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
The ABO Blood Group
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Multiple Allele Traits

