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Positive correlations between cerebral choline and renal dysfunction in chronic renal failure
Osamu Sasaki1, Noriaki Hattori, Hajime Nakahama
1Division of Hypertension and Nephrology, Department of Internal Medicine, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan. osasaki815@hotmail.com
Neuroradiology
|April 6, 2006
Summary
Chronic renal failure (CRF) alters brain metabolism, indicated by elevated choline-containing compounds (Cho). Hemodialysis (HD) may help correct these metabolic changes in the brain.
Area of Science:
- Neuroscience
- Nephrology
- Biochemistry
Background:
- Cerebral metabolism in chronic renal failure (CRF) is not fully understood.
- This study investigates cerebral metabolites in CRF patients using proton magnetic resonance spectroscopy (MRS).
Purpose of the Study:
- To examine cerebral metabolites in CRF patients.
- To evaluate the effect of hemodialysis (HD) on cerebral metabolism in CRF.
Main Methods:
- Proton MRS was used to measure metabolite concentrations (N-acetyl group, creatine, choline-containing compounds, myo-inositol, glutamate + glutamine) in the parietal gray and white matter of 19 CRF patients and 21 controls.
- MRS was performed before and after initiating HD in 9 CRF patients, with a third scan after 18 months in 6 patients.
Main Results:
- CRF patients showed elevated choline-containing compounds (Cho)/creatine (Cr) ratios in both gray and white matter compared to controls.
- Elevated Cho/Cr ratios correlated positively with serum osmotic pressure.
- While no immediate changes were observed after starting HD, the elevated Cho/Cr ratio significantly reduced in gray matter after 18 months of HD.
Conclusions:
- Choline-containing compounds (Cho) play a role in regulating cerebral metabolism to compensate for altered serum osmotic pressure in CRF.
- Hemodialysis (HD) shows potential in correcting abnormal cerebral metabolism associated with CRF.
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