[Cardiac MR tagging: optimization of sequence parameters and comparison at 1.5 T and 3.0 T in a volunteer study]

The aim of this study was the optimization of a gradient echo (GRE) MR tagging sequence at 3.0 T in comparison to 1.5 T in order to obtain the best image contrast between the myocardium, tag lines and blood signal. Theoretically expected improvements of signal-to-noise (SNR) and contrast-to-noise ratios (CNR) were also calculated.

14 healthy volunteers (8 male, 6 female; mean age 43.4 +/- 10.3 years) were scanned using a 3.0 T as well as a 1.5 T whole-body system. A GRE flash-2 D tagging sequence was evaluated (midventricular short axis view) by varying the flip angle (8 - 16 degrees ), slice thickness (4 - 8 mm; fixed flip angle 1.5/3.0 T: 12 degrees /8 degrees , tag size 8 mm) and tag size (4 - 8 mm, fixed flip angle 1.5/3.0 T: 12 degrees /8 degrees , slice thickness 6 mm). The field of view, acquisition time and temporal resolution (45 ms) were kept constant. Qualitative and quantitative image analysis was performed by calculating the SNR, CNR (tag) as well as the relative contrast between the myocardium and tag lines (RCMT).

Based on individual comparison, the best imaging protocol was found at a slice thickness of 6 mm, tag size of 8 mm, optimized flip angle of 8 degrees (3.0 T) and 12 degrees (1.5 T), respectively. Compared to 1.5 T, a significantly higher overall image score was determined (mean +/- sd; 3.2 +/- 0.2 vs. 2.7 +/- 0.4) and a strong correlation between the CNR (tag) and RCMT for flip angle alpha and the slice thickness was found. A higher field strength resulted in an 80 % increase in the CNR (tag) compared to 1.5 T (mean 10.7/6.1). Furthermore, the SNR was improved by 35 % (mean 20.6/15.3) and the RCMT by 35 % (mean 0.47/0.35).

Myocardial tagging at 3.0 T has shown superior image quality in comparison to 1.5 T due to a higher baseline SNR and an improved CNR as well as RCMT. The suppressed fading of the tags enables the accessibility to the diastolic phase of the cardiac cycle.