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Related Experiment Videos

Adrenocortical function testing in dairy cows and its effect on milk yield.

J H van der Kolk1, H J Breukink, T Wensing

  • 1Department for Large Animal Medicine and Nutrition, Veterinary Faculty, University of Utrecht, The Netherlands.

The Veterinary Quarterly
|July 1, 1991
PubMed
Summary

A 6 IU dose of synthetic adrenocorticotropic hormone (ACTH1-24) effectively stimulates cortisol release in cows without impacting milk yield. This dosage is suitable for evaluating adrenocortical function in lactating cattle.

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Area of Science:

  • Veterinary Endocrinology
  • Animal Physiology

Background:

  • Adrenocortical function is crucial for animal health and productivity.
  • Standardized testing is needed to assess adrenal gland function in lactating cows.

Purpose of the Study:

  • To determine an effective dose of synthetic ACTH1-24 for stimulating cortisol release in Holstein-Friesian cows.
  • To evaluate the impact of this dose on milk production.

Main Methods:

  • Intravenous administration of 6 IU synthetic ACTH1-24 to six lactating cows.
  • Measurement of plasma cortisol concentrations at baseline and post-injection.
  • Monitoring milk yield for 7 days post-administration.

Main Results:

  • A peak cortisol concentration of 148 +/- 34.2 ng/ml was observed 1 hour after ACTH1-24 injection.

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  • Plasma cortisol returned to basal levels (4.84 +/- 0.83 ng/ml) by 5 hours post-injection.
  • No significant changes in milk yield were detected up to 7 days after ACTH administration.

    • Conclusions:

    • A 6 IU dose of synthetic ACTH1-24 is sufficient to elicit a significant cortisol response in lactating cows.
    • This dosage does not adversely affect milk production.
    • The 6 IU ACTH1-24 dose is proposed as a reliable standard for intravenous adrenocortical function testing in lactating cows.