[Changes in the immune status of patients with brain tumors in the pre- and postoperative periods]

Changes of the immune status in patients with glioblastomas and meningiomas during the stages of surgical treatment were studied. Functional activity of lymphocytes suffers to a greater measure in patients in the preoperative period and the ratio of the lymphocyte T- and B-subpopulations changes. Preoperative management including hormonal therapy causes further inhibition of the immune status but has no effect on the degree of neurosensitization of the patients, which may be a risk factor of the development of postoperative complications of infectious-inflammatory neuroallergic etiology. Immunogenesis remains inhibited in the early postoperative period, on the 2nd-3rd day after the operation. By the 7th-10th postoperative day significant restoration of the number and functional activity of lymphocytes is encountered in patients with meningiomas, while in patients with glioblastomas inhibition of lymphocyte proliferative activity persists.