Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anticholinergic substances: A single consistent conformation.

P Pauling1, N Datta

  • 1William Ramsay, Ralph Forster, and Christopher Ingold Laboratories, University College London, Gower Street, London WC1, England.

Proceedings of the National Academy of Sciences of the United States of America
|February 1, 1980
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pool-seq driven proteogenomic database for Group G Streptococcus.

Journal of proteomics·2019
Same author

Planning of births and maternal, child health, and nutritional outcomes: recent evidence from India.

Public health·2019
Same author

Lyme neuroborreliosis: a treatable cause of acute ocular motor disturbances in children.

The British journal of ophthalmology·2015
Same author

Computer simulation of energy use, greenhouse gas emissions, and costs for alternative methods of processing fluid milk.

Journal of dairy science·2014
Same author

Pilot-scale crossflow-microfiltration and pasteurization to remove spores of Bacillus anthracis (Sterne) from milk.

Journal of dairy science·2011
Same author

Identification and characterization of bacterial endophytes of rice.

Mycopathologia·2010
Same journal

The TaMYB55-TaSnRK1α1-TabZIP9 module confers heat stress tolerance in wheat.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Superstatistics approach to turbulent circulation fluctuations.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

A molecular timescale for evolution of cobamide biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Pierre Chambon, a pioneer of molecular biology and gene regulation in eukaryotes.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Granulosa cell glycogen fuels the avascular corpus luteum.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Synthetic essentiality of TRAIL/TNFSF10 in VHL-deficient renal cell carcinoma.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Researchers analyzed 24 acetylcholine antagonists, revealing a single, optimal molecular shape for maximum anticholinergic activity. This finding applies across different crystal structures, offering insights into drug design for nervous system targets.

Area of Science:

  • Pharmacology and Medicinal Chemistry
  • Neuroscience
  • Structural Biology

Background:

  • Acetylcholine antagonists are crucial for modulating nervous system activity.
  • Understanding the precise molecular conformation for optimal activity is key to drug development.
  • Existing crystal structures of antagonists show diverse conformations.

Purpose of the Study:

  • To determine a single, consistent, and energetically favorable conformation for 24 acetylcholine antagonists.
  • To quantitatively describe the ideal molecular structure for maximum anticholinergic activity.

Main Methods:

  • Interactive computer-graphics analysis of 24 known acetylcholine antagonists.
  • Comparison of diverse crystal structure conformations with a derived ideal conformation.

Related Experiment Videos

Main Results:

  • A single, consistent, energetically favorable conformation was identified for all 24 antagonists.
  • This ideal conformation differs from many observed crystal structures.
  • The absolute configuration and ideal conformation for maximal anticholinergic effect were quantitatively defined.

Conclusions:

  • A unified conformational model explains anticholinergic activity across diverse antagonist structures.
  • This provides a quantitative basis for designing novel, potent anticholinergic drugs.
  • The findings advance our understanding of structure-activity relationships in neuropharmacology.