A suggestion for naming faces of ring compounds

Area of Science:

• Chemical nomenclature
• Molecular topology
• Stereochemistry

Background:

• Understanding the interaction topology of cyclic compounds with macromolecules and receptors is essential in various scientific fields.
• Existing nomenclature systems may not adequately describe the spatial orientation of cyclic molecules.
• A standardized system is needed to facilitate clear communication and analysis of molecular interactions.

Purpose of the Study:

• To propose a novel nomenclature system for naming the faces of cyclic compounds.
• To provide a consistent method for describing the topology of interactions involving ring systems.
• To enhance the study of molecular recognition and drug-receptor binding.

Main Methods:

• Development of an alpha/beta-face nomenclature based on ring numbering direction.
• The system utilizes the lowest numbered unshared ring atom as a reference point.
• Application of the nomenclature to diverse cyclic structures, including single rings, fused rings, and polymers.

Main Results:

• The proposed alpha/beta-face nomenclature system is introduced.
• It is based on the direction of ascending numbering from a specific reference atom.
• The system demonstrates broad applicability across various classes of cyclic compounds.

Conclusions:

• The alpha/beta-face nomenclature offers a robust solution for describing cyclic compound topology.
• This system is versatile and applicable to a wide array of molecular structures.
• It provides a valuable tool for researchers studying molecular interactions and designing new therapeutics.