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Drug testing for activity against varicella-zoster virus in hairless guinea pigs
1Division of Infectious Diseases, Children's Hospital Research Foundation, Cincinnati, OH 45229-2899.
Antiviral Research
|May 1, 1991
Abstract:
Inoculation of congenitally hairless guinea pigs with varicella-zoster virus (VZV) (Oka strain) results in a self-limited exanthematous infection analogous to varicella in children. Administration of acyclovir or 6-methoxypurine arabinoside modified the course of infection. This model should facilitate pre-clinical testing of putative anti-VZV agents.