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Updated: Aug 9, 2026

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
Published on: March 31, 2015
"Hopeful monsters," transposons, and Metazoan radiation
1Department of Geological Sciences, University of California, Santa Barbara, CA 93106.
Abstract:
The appearance of many novel morphologies, frequently expressed taxonomically as new phyla, classes, or orders, occurs with such rapidity in evolutionary time that microevolutionary substitutions involving structural genes seem an implausible mechanism. It has been suggested that such novelties are produced by changes in developmental and regulatory structures and patterns rather than by an accumulation of single structural gene changes. The horizontal transmission of genetic material via RNA-based viruses between members of a population may rapidly create intrafertile sub-populations that differ markedly from their parents and form the basis of new morphological types, avoiding the usual fitness problems associated with "hopeful monsters."
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