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Updated: Aug 9, 2026

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Lignin degradation by peroxidase in organic media: A reassessment
N G Lewis1, R A Razal, E Yamamoto
1Wood Chemistry and Biochemistry, Department of Forest Products, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061.
Abstract:
The effect of horseradish peroxidase/H(2)O(2) in organic medium (dioxane/aqueous buffer, pH 5, 95:5) on the depolymerization of synthetic (dehydrogenatively polymerized) lignin was reinvestigated. In contrast to previous claims [Dordick, J. S., Marletta, M. A. & Klibanov, A. M. (1986) Proc. Natl. Acad. Sci. USA 83, 6255-6257], our results demonstrated that vigorous depolymerization of this substrate did not occur. Further, during this treatment ferulic acid was not a significant biodegradation product.
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