Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bactericidal effects of plasma-generated cluster ions.

I Digel1, A Temiz Artmann, K Nishikawa

  • 1University of Applied Sciences Aachen, Germany. digel@fh-aachen.de

Medical & Biological Engineering & Computing
|April 6, 2006
PubMed
Summary

Plasma-generated cluster ions (PCIs) effectively kill bacteria by damaging their membranes and surface proteins. This novel air purification technology shows potential for enhanced indoor air quality by targeting common indoor microbes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Field-Based Planetary Protection Operations for Melt Probes: Validation of Clean Access into the Blood Falls, Antarctica, Englacial Ecosystem.

Astrobiology·2023
Same author

Synthesis, characterization, in vitro biocompatibility and antibacterial properties study of nanocomposite materials based on hydroxyapatite-biphasic ZnO micro- and nanoparticles embedded in Alginate matrix.

Materials science & engineering. C, Materials for biological applications·2019
Same author

Thermal fluctuations of haemoglobin from different species: adaptation to temperature via conformational dynamics.

Journal of the Royal Society, Interface·2012
Same author

Molecular processes in biological thermosensation.

Journal of biophysics (Hindawi Publishing Corporation : Online)·2010
Same author

Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes.

Medical & biological engineering & computing·2009
Same author

From powder to solution: hydration dependence of human hemoglobin dynamics correlated to body temperature.

Biophysical journal·2009

Area of Science:

  • Environmental Science
  • Microbiology
  • Plasma Physics

Background:

  • Air purification technologies utilize plasma-generated cluster ions (PCIs) for their antimicrobial properties.
  • The precise mechanisms by which PCIs exert lethal effects on microorganisms remain largely uncharacterized.

Purpose of the Study:

  • To evaluate the bactericidal efficacy of PCI technology against common indoor microorganisms.
  • To investigate the underlying mechanisms responsible for PCI-induced bacterial inactivation.

Main Methods:

  • Time/dose-dependent experiments were conducted on Staphylococcus, Enterococcus, Micrococcus, and Bacillus species.
  • Bacterial membrane integrity and surface protein composition were analyzed using SDS PAGE and 2D PAGE.
  • Electrophoretic analysis was performed to assess potential DNA and cytoplasm protein damage.

Related Experiment Videos

Main Results:

  • PCIs demonstrated rapid inhibiting effects within minutes, leading to 99.9% irreversible bacterial destruction within 2-8 hours.
  • PCI exposure caused significant damage to bacterial cell membranes.
  • SDS PAGE and 2D PAGE revealed alterations in bacterial surface protein composition, with no detectable damage to DNA or cytoplasm proteins.

Conclusions:

  • The primary antimicrobial action of PCIs involves chemical modification of bacterial surface proteins.
  • In situ hydroxyl radical formation on bacterial surfaces is proposed as the key mechanism driving protein damage.
  • PCI technology offers a promising approach for air purification, with its efficacy linked to surface protein modification rather than DNA damage.