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A semi-parametric method for describing the age-specific distribution of clinical measurements in cross-sectional
Mohd Muzibur Rahman1, Kenichi Satoh, Keiko Otani
1Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
Abstract:
Age-specific distribution of clinical measurements in cross-sectional study is described in this paper. Since the distribution of measurements usually varies with age, a model with an age-dependent structure is needed. We propose here a statistical method for describing the age-specific distribution using an extension of the power-normal-model. The age-dependent parameters are to be estimated through a nonparametric smoothing technique based on the local likelihood method. As a consequence, we can compute a smoothed percentile curve of measurements with reference to age. Several kinds of clinical measurements are analyzed to determine the proposed method.
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