Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperphosphatasemia in Scottish terriers: 7 cases.

Alexander E Gallagher1, David L Panciera, Roger J Panciera

  • 1Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg 24061, USA.

Journal of Veterinary Internal Medicine
|April 6, 2006
PubMed
Summary

This study investigated elevated serum alkaline phosphatase (ALKP) in Scottish Terriers, finding a potential familial disorder causing hyperphosphatasemia without liver abnormalities. Further research is needed to fully characterize this condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thyroid function tests during nonthyroidal illness syndrome and recovery in acutely ill dogs.

Journal of veterinary internal medicine·2023
Same author

Influence of medications on thyroid function in dogs: An update.

Journal of veterinary internal medicine·2023
Same author

Evaluation of gallbladder motility assessed by ultrasonography in dogs with hyperlipidemia.

Journal of veterinary internal medicine·2023
Same author

Endoscopic application of fibrin glue may be a feasible method of treatment for postintubation tracheal lacerations in cats.

American journal of veterinary research·2023
Same author

Gastroduodenal ulceration in dogs with liver disease.

Journal of veterinary internal medicine·2022
Same author

Evaluation of hemostasis in hyperthyroid cats.

Journal of veterinary internal medicine·2021

Area of Science:

  • Veterinary Medicine
  • Canine Pathology
  • Biochemistry

Background:

  • Elevated serum alkaline phosphatase (ALKP) is a frequent finding in canine patients.
  • A cohort of seven Scottish Terriers presented with unexplained hyperphosphatasemia.

Observation:

  • Five of the seven affected dogs were genetically related.
  • ALKP activity levels varied significantly, with some exceeding 17 times the reference range.
  • Elevated ALKP persisted for over six months in multiple dogs, with five dogs exceeding 1,000 U/L at some point.

Findings:

  • Standard liver and adrenocortical function tests, along with hepatic ultrasonography, yielded normal results in most dogs.
  • Histopathological examination revealed normal liver tissue in six dogs; one dog had mild cholangitis not consistent with the degree of hyperphosphatasemia.

Related Experiment Videos

  • The findings suggest a possible benign hyperphosphatasemia or an asymptomatic familial disorder in Scottish Terriers.

    • Implications:

    • This research highlights a potential inherited condition in Scottish Terriers characterized by elevated ALKP without apparent liver disease.
    • Further investigation into ALKP isoenzymes, skeletal health, and broader population studies is warranted.
    • Definitive characterization of this familial hyperphosphatasemia requires ongoing prospective research.