fMRI of lexical-semantic priming in a chronic schizophrenia patient

A neuropsychological hallmark of schizophrenia is a breakdown in semantic association networks that often impacts language and formal thought. Although computational models simulating this breakdown exist, studies have yet to investigate this phenomena using functional MRI (fMRI) coupled with an auditory lexical-decision semantic priming paradigm. Thus, this serves to functionally map brain activation to word pairs that differed with respect to a concept called "connectivity" in a patient with schizophrenia and a demographically matched control adult. Analyses revealed a striking difference with respect to the expected stepwise modulation of activation, with the control participant showing significantly greater areas of modulation than the participant with schizophrenia in regions classically implicated in language. Although the results are tentative because of the nature of this investigation (single-case study), they further support the characterization of schizophrenia as a breakdown in lexical-semantic association networks and represent one of the first fMRI studies of semantic priming in schizophrenia informed by a computer model.