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Updated: Aug 9, 2026
Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump
Published on: March 11, 2017
Leaching of diethylhexyl phthalate from polyvinyl chloride materials into etoposide intravenous solutions
Mário L de Lemos1, Linda Hamata, Thanh Vu
1British Columbia Cancer Agency, Vancouver, BC, V5Z 4E6, Canada. mdelemos@bccancer.bc.ca
Abstract:
Etoposide intravenous solution is associated with leaching of diethylhexyl phthalate (DEHP) from bags and tubings made from polyvinyl chloride (PVC). Recent evidence suggests that this may be more substantial than previously found. Since DEHP is potentially hepatotoxic and carcinogenic, it is preferable to prepare and administer etoposide bags and tubings made from non-PVC materials.
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