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Early cleavage morphology affects the quality and implantation potential of day 3 embryos
Haydar Nadir Ciray1, Levent Karagenç, Ulun Ulug
1Bahceci Women Health Care Center, German Hospital, Istanbul, Turkey.
Objective:
To assess the development and implantation potential of early-cleaved embryos displaying various morphological patterns.
Design:
Retrospective analysis.
Setting:
Private IVF center.
Patient(S):
Embryos obtained from 1,556 transfer cycles were assessed. Early-cleaved embryos were grouped according to their cleavage patterns as: even (1,490); uneven (3,238); and fragmented (768), or according to nuclear morphologies as: mononucleation (2,008) and other nuclear morphologies; nonmononucleation (3,488). Seven thousand four hundred forty-five embryos were late cleaved.
Intervention(S):
None.
Main Outcome Measure(S):
Embryo quality, pregnancy (PR), and implantation rates.
Result(S):
Day 3 embryo quality was highest in evenly early-cleaved embryos and in those displaying mononucleation. Early-cleaved embryos displaying fragmentation and late-cleaved embryos yielded the poorest day 3 quality. Early cleavage cycles displayed higher PR and implantation rate than late cleavage with the exception of other nuclear morphologies, in which similar outcome was obtained. Mononucleated early-cleaved embryos implanted at a higher frequency than early-cleaved embryos displaying other nuclear morphologies.
Conclusion(S):
The morphology of early cleavage correlates to day 3 embryo quality and implantation rate.
