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Effect of millimeter waves on cyclophosphamide induced NF-kappaB
M K Logani1, M Natarajan, V R Makar
1Richard J. Fox Center for Biomedical Physics, Temple University School of Medicine, Philadelphia, Pennsylvania 19104, USA. mlogani@temple.edu
Abstract:
Antiapoptotic activity of NF-Kappa B (NF-kappaB) in tumors contributes to acquisition of resistance to chemotherapy. The effect of millimeter waves (MMWs) on NF-kappaB activation induced by cyclophosphamide (CPA) was studied in the spleen of mice. CPA, an anticancer drug, caused a marked increase (58.9-fold) in NF-kappaB DNA-binding activity as compared to the control group. No significant enhancement in NF-kappaB activity (0.51-fold) was observed when the CPA group was also irradiated with MMWs. These results suggest that treatment with MMWs can inhibit activation of NF-kappaB induced by chemotherapeutic drugs.
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