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Lipid peroxidation in fatty liver induced by caffeine in rats
M U Dianzani1, G Muzio, M E Biocca
1Department of Medicine and Experimental Oncology, University of Turin, Italy.
International Journal of Tissue Reactions
|January 1, 1991
Abstract:
An increase in lipid peroxidation has been found in liver after poisoning with hepatotoxic substances and following dietary changes, i.e. choline-devoid diet and orotic acid-rich diet. In this study we analysed in the rat a model of fatty liver induced by administration of caffeine. The results seem to indicate an increased peroxidability in the liver of caffeine-treated animals, due to an increase in triglyceride content. A decrease of vitamin E which also occurs might contribute to the lipid peroxidation.