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Related Experiment Videos

The Siblings With Ischemic Stroke Study (SWISS): a progress report.

James F Meschia1, Brett M Kissela, Thomas G Brott

  • 1Department of Neurology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, Florida 32224, USA. meschia.james@mayo.edu

Clinical Medicine & Research
|April 6, 2006
PubMed
Summary

Genetic factors, like the PDE4D gene, are linked to ischemic stroke. The Siblings With Ischemic Stroke Study (SWISS) faces challenges with family enrollment but uses innovative methods to improve participation.

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Area of Science:

  • Genetics
  • Neurology
  • Epidemiology

Background:

  • Growing evidence links genetic factors to ischemic stroke.
  • The phosphodiesterase 4D (PDE4D) gene on chromosome 5q12 is a recent focus of genetic stroke research.
  • Conducting genetic studies for stroke presents significant logistical challenges.

Purpose of the Study:

  • To review the design of the Siblings With Ischemic Stroke Study (SWISS).
  • To discuss challenges encountered in a sibling-based pedigree study using proband-initiated consent.
  • To update on SWISS enrollment progress and describe strategies to overcome enrollment barriers.

Main Methods:

  • The SWISS study utilizes a sibling-based pedigree design.
  • Proband-initiated consent is employed to protect family member privacy.

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  • The study tracks enrollment progress and identifies barriers to pedigree completion.

    • Main Results:

    • Proband-initiated enrollment, while protecting privacy, leads to a high rate of incomplete pedigrees (3-4 probands needed per completed pedigree).
    • The SWISS study is actively enrolling participants and encountering specific enrollment barriers.
    • Innovative approaches are being implemented to enhance enrollment and improve pedigree completion rates.

    Conclusions:

    • Sibling-based genetic stroke studies are valuable but logistically complex.
    • Balancing participant privacy with study completion requires careful methodological consideration.
    • The SWISS study demonstrates ongoing efforts to optimize enrollment strategies for genetic research in ischemic stroke.