Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Data and animal management software for large-scale phenotype screening.

Keith A Ching1, Michael P Cooke, Lisa M Tarantino

  • 1Genomics Institute, Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA. mousetracs@users.sourceforge.net

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|April 6, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling gene regulatory perturbations via deep learning from high-throughput reporter assays.

bioRxiv : the preprint server for biology·2026
Same author

A shared genetic regulator of metabolism and addiction-related behavior in mice and humans.

bioRxiv : the preprint server for biology·2026
Same author

Antigen reactivity defines tissue-resident memory and exhausted T cells in tumors.

Nature immunology·2025
Same author

Genetic mapping in collaborative cross mouse strains identifies loci that affect initial sensitivity to cocaine.

Psychopharmacology·2025
Same author

Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations.

Psychopharmacology·2025
Same author

Antigen reactivity defines tissue-resident memory and exhausted T cells in tumours.

bioRxiv : the preprint server for biology·2025
Same journal

Correction: Are we fully exploiting genetic discoveries to understand and treat Alzheimer's disease?

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Neuroinflammation in glaucoma: a myriad of cellular pathways and players.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Correction: THBS1: a biomarker for PCOS and its role in pathogenesis via the PI3K/AKT signaling pathway.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Elucidating the therapeutic targets and multi-target mechanisms of salvianolic acid A for diabetic nephropathy.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

DeepDisSNP: Predicting disease-associated SNPs by representation learning on disease and SNP linkage disequilibrium networks.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

A comprehensive full-length transcriptome atlas across multiple organs of an Indian yak breed-Arunachali.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
See all related articles

MouseTRACS is a Web-based system that streamlines mouse mutagenesis research by managing animal husbandry and analyzing phenotype screens. This informatics tool aids in identifying mutants and novel gene functions through integrated data visualization and genetic mapping.

Area of Science:

  • Genetics
  • Bioinformatics
  • Laboratory Informatics

Background:

  • The Genomics Institute of the Novartis Research Foundation (GNF) employs a mouse N-ethyl-N-nitrosourea (ENU) mutagenesis program.
  • Efficient management of mouse colonies and analysis of large-scale phenotype screening data are critical for genetic research.

Purpose of the Study:

  • To introduce MouseTRACS, a Web-based laboratory informatics system designed for the GNF's mouse ENU mutagenesis program.
  • To detail MouseTRACS's capabilities in managing animal husbandry, analyzing phenotype screens, and facilitating the identification of novel gene functions.

Main Methods:

  • MouseTRACS electronically records and organizes mouse colony operations, including animal husbandry and IACUC protocol usage.
  • The system integrates phenotype and genotype data using likelihood odds ratio (LOD) plots and single nucleotide polymorphism (SNP) markers for mutation mapping.

Related Experiment Videos

  • Data visualization is achieved through standard charts (box plots, histograms, scatter plots) and customized comparative analyses.

    • Main Results:

    • MouseTRACS enables efficient screening, analysis, and management of thousands of animals in mutagenesis programs.
    • The system facilitates the identification of mutant mice and the discovery of novel gene functions.
    • Dynamic generation of pedigree diagrams and inventory reports aids in summarizing inheritance patterns and penetrance.

    Conclusions:

    • MouseTRACS provides a comprehensive solution for managing complex mouse mutagenesis programs.
    • The informatics system enhances the efficiency of phenotype screening, data analysis, and genetic mapping.
    • MouseTRACS is available as an open-source tool to support broader scientific research.