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Brain Imaging

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Related Experiment Video

Updated: Jul 27, 2026

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

Published on: March 12, 2019

Imaging of the brain cannabinoid system.

K P Lindsey¹, S T Glaser, S J Gatley

¹Center for Translational Neuroimaging, Brookhaven National Laboratory, 30 Bell Avenue, Upton, NY 11973, USA. klindsey@mclean.harvard.edu

Handbook of Experimental Pharmacology

|April 7, 2006

Summary

Brain imaging of the cannabinoid system uses autoradiography and in vivo neuroimaging. While autoradiography provides detailed receptor distribution, in vivo techniques require further ligand development for comprehensive understanding of cannabinoid drug effects.

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Last Updated: Jul 27, 2026

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets

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Area of Science:

Neuroscience
Pharmacology
Medical Imaging

Background:

The brain cannabinoid system plays a crucial role in various physiological processes.
Understanding the distribution and effects of cannabinoid drugs is essential for therapeutic and research purposes.

Purpose of the Study:

To review and compare two primary strategies for imaging the brain cannabinoid system: autoradiography and in vivo neuroimaging.
To highlight the current state and future directions of cannabinoid system research using imaging techniques.

Main Methods:

Autoradiography: Direct imaging of cannabinoid receptors in brain slices using radiolabeled ligands and indirect imaging of drug effects via blood flow or metabolism indicators.
In vivo neuroimaging: Noninvasive techniques like PET, SPECT, and MRI for visualizing drug binding and effects in living brains.

Main Results:

Autoradiography has yielded high-quality data on cannabinoid receptor distribution and drug-induced metabolic changes.
In vivo neuroimaging of cannabinoid systems is in its early stages, with promising but generalizable results pending.

Conclusions:

Autoradiography offers valuable insights into cannabinoid receptor localization and drug effects.
Advancements in in vivo neuroimaging ligands are critical for fully elucidating the complexities of the brain cannabinoid system in living subjects.