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Updated: Aug 9, 2026

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
[Expression of cyclooxygenase-2 and vascular endothelial growth factor in human prostate cancer and its significance]
Tie-xiong Jin1, Xiao-gang Li, Wen-yuan Wu
1Department of Urology, the Affiliated Hospital to Medical College, Yanbian University, Yanji, Jilin, China. jintiexiong@yeah.net
Objective:
To evaluate expressions of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) in primary prostate cancer and its clinical significance.
Methods:
Expressions of COX-2 and VEGF were detected by immunohistochemical assay in tissues of 40 prostate cancer and 10 benign prostatic hyperplasia samples.
Results:
COX-2 and VEGF levels in prostate cancer were much higher than those in BPH. The degrees of cancer malignancy and invasion positively correlated with the expressions of COX-2 and VEGF. COX-2 level positively correlated with VEGF level.
Conclusion:
The abnormal expression of COX-2 plays an important role in the development of primary prostate cancer. COX-2 and VEGF are good molecular markers of prostate cancer which are hopeful to be used for the assistant diagnosis and the prediction of prognosis of prostate cancer.
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