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Published on: March 14, 2015
[Effects of senility on inducible nitric oxide synthase expression and cell apoptosis in rat penis]
Bo Liu1, Ji-hong Liu, Tao Wang
1Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Objectives:
To investigate the effect of senility on inducible nitric oxide synthase (iNOS) expression and apoptosis in rat penis.
Methods:
The rats were divided into three groups randomly: senescent, aged and young. Their penises were harvested to detect iNOS expression by immunohistochemistry and cell apoptosis rate by TUNEL, respectively.
Results:
iNOS expression were 0.24 +/- 0.03, 0.17 +/- 0.02, 0.12 +/- 0.03 (relative A) and cell apoptosis rate were (1.41 +/- 0.78)%, (0.94 +/- 0.43)% and (0.50 +/- 0.23 )%, respectively, in the tissues of three groups. The differences among three groups were considerable significance (P <0.05).
Conclusion:
It maybe one of the mechanisms of erectile dysfunction in the aging male that senility causes the increase of iNOS expression and cell apoptosis.
