Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mortality in Prader-Willi syndrome.

Stewart L Einfeld1, Sophie J Kavanagh, Arabella Smith

  • 1University of New South Wales, Sydney, New South Wales. s.einfeld@unsw.edu.au

American Journal of Mental Retardation : AJMR
|April 7, 2006
PubMed
Summary

People with Prader-Willi syndrome face a significantly higher mortality risk compared to others with intellectual disability. Obesity and its complications are key factors contributing to this increased risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Caregiver and Care Recipient Perspectives on Paediatric ED Mental Health Presentations: A Qualitative Study.

Emergency medicine Australasia : EMA·2026
Same author

Developing Scotch tape exfoliation methods for two-dimensional magnetic metal-organic frameworks.

Chemical communications (Cambridge, England)·2026
Same author

Psychological Distress Trajectories of Parents of Children With Developmental Disabilities Participating in a Parenting Intervention.

Journal of intellectual disability research : JIDR·2025
Same author

Schizotypal Traits in Children with Autism Spectrum Disorder and the Impact on Social, Emotional and Behavioral Functioning.

Brain sciences·2025
Same author

Paediatric Emergency Department Mental Health and Behavioural Presentations in Australia Before and After the Onset of the COVID-19 Pandemic: Retrospective Observational Study.

Journal of paediatrics and child health·2025
Same author

Childhood and Adulthood Predictors of Community Participation by Autistic Adults With and Without Intellectual Disability.

Journal of applied research in intellectual disabilities : JARID·2024

Area of Science:

  • Medical research
  • Genetics
  • Public Health

Background:

  • Prader-Willi syndrome (PWS) is associated with a high mortality rate.
  • Intellectual disability (ID), common in PWS, also increases mortality risk.
  • Existing data lacks direct comparison of mortality between PWS and other ID populations.

Purpose of the Study:

  • To compare mortality rates in a PWS cohort with a control group of individuals with ID from other causes.
  • To identify specific factors contributing to mortality in PWS.

Main Methods:

  • Longitudinal cohort study design.
  • Comparison of death rates between PWS individuals and an epidemiologically derived control sample with ID.
  • Statistical analysis to determine hazard ratios, adjusting for intellectual function levels.

Related Experiment Videos

Main Results:

  • Individuals with PWS exhibited a higher mortality rate than the control group.
  • The hazard ratio for PWS versus controls was 6.07 after accounting for intellectual disability.
  • Obesity and its associated complications were identified as significant contributors to mortality in the PWS group.

Conclusions:

  • Prader-Willi syndrome confers a substantially elevated mortality risk independent of intellectual disability.
  • Obesity management is crucial for improving survival rates in individuals with PWS.