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Related Experiment Video

Updated: Feb 28, 2026

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

Published on: November 6, 2018

Amphetamine exposure enhances habit formation.

Andrew Nelson¹, Simon Killcross

¹School of Psychology, Cardiff University, Cardiff, CF10 3AT, United Kingdom.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|April 7, 2006

Summary

This summary is machine-generated.

Amphetamine sensitization accelerates the shift from goal-directed actions to stimulus-response (S-R) habits in rats. This sensitization, particularly before training, impairs the ability to adjust behavior based on reward value changes.

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Area of Science:

Neuroscience
Behavioral Science
Pharmacology

Background:

Instrumental actions transition from goal-directed to habit-based with extensive training.
Dopaminergic system sensitization may influence this transition speed.

Purpose of the Study:

To investigate if amphetamine sensitization accelerates the shift from goal-directed to habit-based instrumental responding.
To determine the effect of sensitization timing on this behavioral transition.

Main Methods:

Rats were subjected to amphetamine sensitization before or after instrumental training.
An instrumental devaluation task was used to assess goal-directed behavior.
Behavioral sensitivity to outcome value changes was measured.

Main Results:

Pre-training sensitization resulted in persistent responding despite outcome devaluation, indicating a shift to habit.
Post-training sensitization did not disrupt established goal-directed behavior.
Sensitized rats showed an inability to use outcome representations to guide behavior.

Conclusions:

Amphetamine sensitization before training rapidly promotes habit formation in instrumental tasks.
Sensitization does not impair the performance of already established goal-directed actions.
Dopaminergic sensitization influences the developmental trajectory of action control.