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Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Coronary reoperation with and without cardiopulmonary bypass
S M Tugtekin1, K Alexiou, U Kappert
1Dep. of Cardiac Surgery, Heart Center Dresden University Hospital, Fetscherstr. 76, 01307 Dresden, Germany. stugtekin@herzzentrum-dresden.com
Insights
Redo coronary artery bypass grafting (CABG) is safe with comparable mortality whether using cardiopulmonary bypass (CPB) or not. However, off-pump redo CABG may lead to incomplete revascularization, impacting long-term outcomes.
Area of Science:
- Cardiovascular Surgery
- Cardiac Surgery Outcomes
- Minimally Invasive Cardiac Surgery
Background:
- Redo coronary artery bypass grafting (CABG) carries higher risks than primary CABG.
- Myocardial protection strategies during on-pump redo CABG are debated.
- Off-pump redo CABG offers potential advantages by maintaining native coronary flow and avoiding aortic cross-clamping.
Purpose of the Study:
- To compare the outcomes of redo coronary artery bypass grafting (CABG) performed with and without cardiopulmonary bypass (CPB).
Main Methods:
- Retrospective study of 195 patients undergoing redo CABG between January 1998 and May 2004.
- Patients were divided into two groups: on-pump redo CABG (n=160) and off-pump redo CABG (n=35).
- Outcomes assessed included perioperative mortality, morbidity, revascularization completeness, and long-term survival.
Main Results:
- Perioperative mortality rates were similar between on-pump (3.8%) and off-pump (2.9%) redo CABG groups (p=0.90).
- Complete revascularization was significantly higher in the on-pump group (86.9%) compared to the off-pump group (48.6%) (p < 0.01).
- Average graft number was higher in the on-pump group (2.8 vs 1.6, p=0.04); long-term survival rates were comparable (83.8% vs 88.6%, p=0.92).
Conclusions:
- Both on-pump and off-pump redo CABG can be performed safely with low mortality and morbidity.
- Off-pump redo CABG may be associated with a higher risk of incomplete revascularization.
- Patient selection and surgical strategy are crucial for optimizing outcomes in redo CABG procedures.
Abstract:
Redo coronary artery bypass grafting (CABG) is still associated with increased morbidity and mortality compared to primary operation. Myocardial protection is one of the key issues in redo on pump CABG and is still a matter of debate. Off pump redo CABG seems to be an attractive alternative as native coronary blood flow remains and cross clamping of the aorta is avoided. The aim of this retrospective study was to compare the outcome of redo CABG with and without CPB. From 1/1998 to 5/2004 redo CABG was performed in 195 patients (pts): 162 male (83.1%) and 33 female (16.9%) pts, age 66 +/- 9 years. In 160 pts, CPB with isolated antegrade myocardial protection was used for redo CABG. Off pump redo CABG was performed in 35 pts (30 male (85.7%) and 5 female (14.3%), age 67 +/- 8 years). Perioperative overall mortality rate was 3.6% (n = 7) and comparable in both groups (on pump 3.8% versus off pump 2.9%; p = 0.90), as well as perioperative myocardial infarction, intraaortic balloon pump implantation rate and secondary morbidity. Complete revascularization was achieved in 139 pts (86.9%) after on pump CABG and in 17 pts (48.6%) of the off pump group (p < 0.01). The average number of grafts was significantly higher in the on pump group (2.8 +/- 0.78 versus 1.6 +/- 0.6; p = 0.04).Furthermore, 20 pts (12.5%) in the on pump group died during follow-up (50 +/- 16 months). Five pts (25.0%) died due to cardiac reasons. In the off pump group 3 pts (8.6%) died during follow-up (44 +/- 13 months), noncardiac related. Overall survival was 83.8% in the on pump group and 88.6% in the off pump group (p = 0.92). On pump redo CABG and off pump redo CABG can be safely performed with low mortality and morbidity. Off pump redo CABG might be limited due to incomplete revascularization.
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