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Updated: Aug 9, 2026

Polygraphic Recording Procedure for Measuring Sleep in Mice
Published on: January 25, 2016
CSF prostaglandin D synthase is reduced in excessive daytime sleepiness
Claudio L Bassetti1, Martin Hersberger, Christian R Baumann
1Department of Neurology, Universitätsspital Zürich, Frauenklinikstrasse 26, 8091 Zürich, Switzerland. claudio.bassetti@usz.ch
Abstract:
Lipocalin-type prostaglandin D synthase (L-PGDS) is a brain enzyme, which produces prostaglandin D(2), a substance with endogenous somnogenic effects. Using a standardized protocol for immunonephelometric determination of cerebrospinal fluid (CSF) L-PGDS levels, we show that CSF L-PGDS levels are significantly lower in 34 patients with excessive daytime sleepiness when compared with levels in 22 healthy controls. Thus, L-PGDS may represent the first neurochemical measure of excessive daytime sleepiness.
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